2088463-66-3
2088463-66-3 structure
- Name: VBIT-3
- Chemical Name: VBIT-3
- CAS Number: 2088463-66-3
- Molecular Formula: C21H19ClF3N3O3
- Molecular Weight: 453.84
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-24 01:11:51
- Modify Date: 2025-08-27 12:01:56
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VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].
| Name | VBIT-3 |
|---|
| Description | VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1]. |
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| Related Catalog | |
| Target |
Kd: 31.3 μM (VDAC1)[1] Apoptosis[1] |
| In Vitro | VBIT-3 targets the mitochondrial protein VDAC1, inhibit apoptosis and protect against mitochondria dysfunction[1]. VBIT-3 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50s of 8.8±0.56 μM, 6.6±1.03 μM, and 7.5±0.27 μM, respectively[1]. Apoptosis Analysis[1] Cell Line: HEK-293 cells Concentration: 0.1, 1, and 10 μM Incubation Time: Result: Inhibited apoptosis with an IC50 of 7.5±0.27μM. |
| References |
| Molecular Formula | C21H19ClF3N3O3 |
|---|---|
| Molecular Weight | 453.84 |