BI-8668

Names

[ CAS No. ]:
2084059-97-0

[ Name ]:
BI-8668

Biological Activity

[Description]:

BI-8668 (BI 8668) is a highly potent and selective epithelial sodium channel (ENaC) inhibitor, inhibits Na+ current with IC50 of 17 nM (Ussing chamber assay);BI-8668 inhibits ENaC-mediated water permeability through cell monolayers of the cell line M-1 (M-1 cells: mouse kidney tubules cells) with 81% inhibition at 3 uM.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₂Cl₂N₈O₂

[ Molecular Weight ]:
523.463

Related Compounds

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