CDK2 inhibitor 73

Names

[ CAS No. ]:
2079895-42-2

[ Name ]:
CDK2 inhibitor 73

Biological Activity

[Description]:

CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

cdk2/cyclin A:44 nM (IC50)

Cdk1/cyclin B:86 μM (IC50)

[References]

[1]. Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₈N₆O₂S

[ Molecular Weight ]:
442.49

[ Storage condition ]:
2-8℃

CDK2 inhibitor 73

Names

Biological Activity

Chemical & Physical Properties

Related Compounds