2079895-42-2

2079895-42-2 structure

Name: CDK2 inhibitor 73
Chemical Name: CDK2-IN-4
CAS Number: 2079895-42-2
Molecular Formula: C₂₃H₁₈N₆O₂S
Molecular Weight: 442.49
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2019-08-03 21:53:58
Modify Date: 2024-01-07 21:45:14
CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1].

Name	CDK2-IN-4

Description	CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	cdk2/cyclin A:44 nM (IC50) Cdk1/cyclin B:86 μM (IC50)
References	[1]. Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767.