Rovanersen

Names

[ CAS No. ]:
2072901-32-5

[ Name ]:
Rovanersen

Biological Activity

[Description]:

Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

In vitro, Rovanersen (WVE-120101) leads to the selective RNase H cleavage of mutant Huntingtin allele (mHTT) over wtHTT, with no complement activation. Rovanersen selectively decreases mHTT mRNA and protein levels compared with wtHTT in multiple cells lines[1].

[In Vivo]

In non-human primates (NHPs), Rovanersen (WVE-120101) is found in nuclear and perinuclear compartments of neurons in brain areas believed to be involved in HD pathology[1].

[References]

[1]. M Meena, et al. Selectivity and Biodistribution of WVE-120101, a Potential Antisense Oligonucleotide Therapy for the Treatment of Huntington’s Disease (S56.001). AAN Enterprises. April 18, 2017; 88 (16 Supplement).

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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