Liraglutide

Names

[ CAS No. ]:
204656-20-2

[ Name ]:
Liraglutide

[Synonym ]:
liraglutide

Biological Activity

[Description]:

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor

Research Areas >> Metabolic Disease

Peptides

[Target]

GLP-1 receptor[1]

[In Vitro]

Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1 that stimulates insulin secretion. Liraglutide is an injectable drug for the treatment of type 2 diabetes, also can be used to treat obesity in adults with some related comorbidity. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells[1].

[Cell Assay]

Raw264.7 macrophage cells are cultured in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum in a humidified 37°C incubator with 5% CO2. The cells are incubated with oxLDL (50 μg/mL), Liraglutide (0.1, 0.5, 1 and 2 nM) or Exendin-3 (9-39) (1, 10 and 100 nM) alone, or in combination[1].

[References]

[1]. Wang Y,et al. Transformation of oligomers of lipidated peptide induced by change in pH.Mol Pharm. 2015 Feb 2;12(2):411-9.

[2]. Wang YG, et al. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.J Geriatr Cardiol. 2015 Jul;12(4):410-416.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇₂H₂₆₅N₄₃O₅₁

[ Molecular Weight ]:
3751.20000

[ Exact Mass ]:
3748.95000

[ PSA ]:
1513.76000

[ LogP ]:
6.12960

[ Storage condition ]:
-20°C