AMPA Receptor Modulator-1

Names

[ CAS No. ]:
2036074-41-4

[ Name ]:
AMPA Receptor Modulator-1

Biological Activity

[Description]:

AMPA Receptor Modulator is a potent, oral active and selective AMPAR regulatory protein TARP γ-8 negative modulator with a pIC50 of 9.7, more selective over GluA1/γ-2 (pIC50=5)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

pIC50: 9.7 (TARP γ-8)[1]


[References]

[1]. Ravula S, et al. Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H11ClF3NO2

[ Molecular Weight ]:
341.71

Related Compounds