7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid

Names

[ CAS No. ]:
20300-59-8

[ Name ]:
7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid

[Synonym ]:
7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid
2H-1-Benzopyran-3-carboxylic acid, 7-methoxy-2-oxo-
7-methoxy-2-oxochromene-3-carboxylic acid

Biological Activity

[Description]:

7-Methoxycoumarin-3-carboxylic acid is a fluorescent dye with an excitation peak at 355 nm and an emission peak at 405 nm. 7-Methoxycoumarin-3-carboxylic acid can be used to label peptide[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

7-Methoxycoumarin-3-carboxylic acid (compound 5) (100 µM; 72 h) shows non-toxic for K562, Daudi, RPMI-8226, and Jurkat cells with IC50s of >100, >100, >100, >100 µM, respectively[1].

[References]

[1]. Wiemer AJ, et al. Evaluation of a 7-Methoxycoumarin-3-carboxylic Acid Ester Derivative as a Fluorescent, Cell-Cleavable, Phosphonate Protecting Group. Chembiochem. 2016 Jan 1;17(1):52-5.

[2]. Mohamed-Anis Alouini, et al. Interaction of fluorescently labeled triethyleneglycol and peptide derivatives with β-cyclodextrin. Chemphyschem. 2014 Feb 24;15(3):444-57.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
424.4±45.0 °C at 760 mmHg

[ Melting Point ]:
194ºC

[ Molecular Formula ]:
C₁₁H₈O₅

[ Molecular Weight ]:
220.178

[ Flash Point ]:
172.4±22.2 °C

[ Exact Mass ]:
220.037170

[ PSA ]:
76.74000

[ LogP ]:
1.56

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.611

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Hydrophobicity of Antifungal β-Peptides Is Associated with Their Cytotoxic Effect on In Vitro Human Colon Caco-2 and Liver HepG2 Cells.

PLoS ONE 11 , e0149271, (2016)

The widespread distribution of fungal infections, with their high morbidity and mortality rate, is a global public health problem. The increase in the population of immunocompromised patients combined...

Related Compounds

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