Boc-Gln-Ala-Arg-AMC · HCl

Names

[ CAS No. ]:
201849-55-0

[ Name ]:
Boc-Gln-Ala-Arg-AMC · HCl

[Synonym ]:
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-glutaminyl-L-alanyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-argininamide hydrochloride (1:1)
L-Argininamide, N-[(1,1-dimethylethoxy)carbonyl]-L-glutaminyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, hydrochloride (1:1)

Biological Activity

[Description]:

Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Others

[Target]

Trypsin[1]

[References]

[1]. Mosztbacher D, et al. Measuring digestive protease activation in the mouse pancreas. Pancreatology. 2020 Mar;20(2):288-292.

[2]. Ko CJ, et al. Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. Oncogene. 2020 Sep;39(37):5950-5963.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₄₃ClN₈O₈

[ Molecular Weight ]:
667.154

[ Exact Mass ]:
666.289246

Related Compounds

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