Z-Leu-OH

Names

[ CAS No. ]:
2018-66-8

[ Name ]:
Z-Leu-OH

[Synonym ]:
N-[(Benzyloxy)carbonyl]-L-leucine
N-(Benzyloxycarbonyl)-L-leucine (N-(Benzyloxycarbonyl)leucine
Z-L-Leucine
EINECS 217-960-3
N-Carbobenzyloxy-L-leucine
(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoic acid
N-Benzyloxycarbonyl-L-leucine
Cbz-L-Leu-OH
Carbobenzoxyleucine
Benzyloxycarbonylleucine
dl-Leucine, N-[(phenylmethoxy)carbonyl]-
N-(Benzyloxycarbonyl)-L-leucine N-(B
(S)-2-(((Benzyloxy)carbonyl)amino)-4-methylpentanoic acid
Z-Leu-OH
N-Benzyloxycarbonylleucine
L-Leucine, N-[(phenylmethoxy)carbonyl]-
N-Cbz-L-leucine
N-[(Benzyloxy)carbonyl]leucine
MFCD00026494
Cbz-L-leucine
Leucine, N-[(phenylmethoxy)carbonyl]-
Benzyloxycarbonyl-L-leucine
N-Carbobenzoxy-L-leucine

Biological Activity

[Description]:

N-[(Phenylmethoxy)carbonyl]-L-leucine is a leucine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
442.8±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₉NO₄

[ Molecular Weight ]:
265.305

[ Flash Point ]:
221.6±26.8 °C

[ Exact Mass ]:
265.131409

[ PSA ]:
75.63000

[ LogP ]:
3.12

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.528

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OH2921000

CHEMICAL NAME :: Leucine, N-carboxy-, N-benzyl ester, L-

CAS REGISTRY NUMBER :: 2018-66-8

BEILSTEIN REFERENCE NO. :: 1253861

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H19-N-O4

MOLECULAR WEIGHT :: 265.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 280 mg/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

Safety Information

[ Symbol ]:

GHS02, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H351-H361d

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R10;R20/22;R37/38;R40;R41

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
OH2921000

[ HS Code ]:
2924299090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%