AZ 1729
Names
[ CAS No. ]:
2016864-46-1
[ Name ]:
AZ 1729
Biological Activity
[Description]:
AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways; produces stimulation of [35S]GTPγS binding with pEC50 7.23, inhibits β-adrenoreceptor agonist-promoted lipolysis in primary mouse adipocytes and promotes chemotaxis of isolated human neutrophils.
[References]
References 1. Bolognini D, et al. J Biol Chem. 2016 Sep 2;291(36):18915-31. View Related Products by Target Free Fatty Acid Receptor (FFAR)
Chemical & Physical Properties
[ Molecular Formula ]:
C18H16FN5OS
[ Molecular Weight ]:
369.418
Related Compounds
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