2016864-46-1
2016864-46-1 structure
- Name: AZ 1729
- Chemical Name: AZ1729
- CAS Number: 2016864-46-1
- Molecular Formula: C18H16FN5OS
- Molecular Weight: 369.418
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-01-11 19:33:49
- Modify Date: 2023-02-01 10:49:29
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AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways; produces stimulation of [35S]GTPγS binding with pEC50 7.23, inhibits β-adrenoreceptor agonist-promoted lipolysis in primary mouse adipocytes and promotes chemotaxis of isolated human neutrophils.
| Name | AZ1729 |
|---|
| Description | AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways; produces stimulation of [35S]GTPγS binding with pEC50 7.23, inhibits β-adrenoreceptor agonist-promoted lipolysis in primary mouse adipocytes and promotes chemotaxis of isolated human neutrophils. |
|---|---|
| References | References 1. Bolognini D, et al. J Biol Chem. 2016 Sep 2;291(36):18915-31. View Related Products by Target Free Fatty Acid Receptor (FFAR) |
| Molecular Formula | C18H16FN5OS |
|---|---|
| Molecular Weight | 369.418 |