3-AQC

Names

[ CAS No. ]:
201216-42-4

[ Name ]:
3-AQC

[Synonym ]:
3-aqc

Biological Activity

[Description]:

3-AQC, a piperazinylquinoxaline derivative, is a potent and competitive 5-HT3 receptor antagonist[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT3 Receptor

[In Vitro]

3-AQC (化合物 7e) 的效力几乎比 Tropisetron (HY-B0072) 强 100 倍。在豚鼠回肠中对 2-methyl-5HT 的拮抗作用的 pA2 为10.2[1]。

[References]

[1]. A Monge, et al. Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives. J Med Chem. 1993 Sep 17;36(19):2745-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₁N₅O₄

[ Molecular Weight ]:
395.41200

[ Exact Mass ]:
395.15900

[ PSA ]:
130.65000

[ LogP ]:
1.52418

Related Compounds

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