AC-ARG-TYR-TYR-ARG-TRP-LYS-NH2

Names

[ CAS No. ]:
200959-47-3

[ Name ]:
AC-ARG-TYR-TYR-ARG-TRP-LYS-NH2

[Synonym ]:
AC-ARG-TYR-TYR-ARG-TRP-LYS-NH2
Ac-RYYRWK amide

Biological Activity

[Description]:

Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[Target]

Kd: 0.071 nM (ORL1 in rat cortical membranes)[1]

[References]

[1]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

[2]. M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₉H₆₉N₁₅O₉

[ Molecular Weight ]:
1012.17000

[ Exact Mass ]:
1011.54000

[ PSA ]:
423.76000

[ LogP ]:
4.80440

Related Compounds

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