IRAP-IN-1

Names

[ CAS No. ]:
2007955-25-9

[ Name ]:
IRAP-IN-1

Biological Activity

[Description]:

IRAP-IN-1 is a selective insulin-regulated aminopeptidase (IRAP) inhibitor with IC50 of 32 nM, >25-fold selectivity over ERAP1 and ERAP2.IRAP-IN-1 reduces IRAP-dependent but not ERAP1-dependent cross-presentation by dendritic cells with nanomolar efficacy.

[References]

1. Paraskevi Kokkala, et al. J Med Chem. 2016 Oct 13;59(19):9107-9123.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₄₀N₃O₄P

[ Molecular Weight ]:
597.696

Related Compounds

MPO-IN-1
ANO1-IN-1
prmt5-in-1
DUBs-IN-1
HCVP-IN-1
GRK2-IN-1
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
4-Bromo-2-chloro-5-cyclopropoxypyridine
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
1-(Furan-3-ylmethyl)-1-(2-methoxyethyl)-3-(4-methoxyphenethyl)urea