IRAP-IN-1

Names

[ CAS No. ]:
2007955-25-9

[ Name ]:
IRAP-IN-1

Biological Activity

[Description]:

IRAP-IN-1 is a selective insulin-regulated aminopeptidase (IRAP) inhibitor with IC50 of 32 nM, >25-fold selectivity over ERAP1 and ERAP2.IRAP-IN-1 reduces IRAP-dependent but not ERAP1-dependent cross-presentation by dendritic cells with nanomolar efficacy.

[References]

1. Paraskevi Kokkala, et al. J Med Chem. 2016 Oct 13;59(19):9107-9123.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₄₀N₃O₄P

[ Molecular Weight ]:
597.696

Related Compounds

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