Thiol-PEG3-acetic acid

Names

[ CAS No. ]:
200291-35-6

[ Name ]:
Thiol-PEG3-acetic acid

[Synonym ]:
Acetic acid,[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]

Biological Activity

[Description]:

Thiol-PEG3-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₆O₅S

[ Molecular Weight ]:
224.27500

[ Exact Mass ]:
224.07200

[ PSA ]:
103.79000

[ LogP ]:
0.05060

Related Compounds

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