Thiol-PEG3-acid

Names

[ Name ]:
Thiol-PEG3-acid

[Synonym ]:
3-{2-[2-(2-Sulfanylethoxy)ethoxy]ethoxy}propanoic acid
MFCD25424073
Propanoic acid, 3-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]-

Biological Activity

[Description]:

Thiol-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
377.5±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₈O₅S

[ Molecular Weight ]:
238.301

[ Flash Point ]:
182.1±26.5 °C

[ Exact Mass ]:
238.087494

[ LogP ]:
-0.30

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.482

Related Compounds

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