200291-35-6

200291-35-6 structure

Name: Thiol-PEG3-acetic acid
Chemical Name: 2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]acetic acid
CAS Number: 200291-35-6
Molecular Formula: C₈H₁₆O₅S
Molecular Weight: 224.27500
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-11-02 08:16:11
Modify Date: 2025-08-25 09:14:15
Thiol-PEG3-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]acetic acid
Synonyms	Acetic acid,[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]

Description	Thiol-PEG3-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.