Pro-Leu-Gly-NH2

Names

[ CAS No. ]:
2002-44-0

[ Name ]:
Pro-Leu-Gly-NH2

[Synonym ]:
Oxytocin C-terminal tripeptide
Melanocyte stimulating hormone release inhibiting factor
MSH-release inhibiting factor I
MIF-I Melanostatin Oxytocin fragment 7-9
L-Prolyl-L-leucylglycinamide
MFCD00037866
MELANOSTATIN
EINECS 217-902-7
Pro-Leu-Gly-NH2
L-Prolyl-L-leucylglycylamide
melanocyte-stimulating hormone release-inhibiting factor-1
MIF-I
Prolylleucylglycine amide
7-9-Oxytocin
MIF-1

Biological Activity

[Description]:

MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects of morphine and stress-induced analgesia (SIA). MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB)[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[In Vitro]

MIF-1 (Melanostatin, 1 μM) provokes a reversible hyperpolarization and a suppression of spontaneous action potentials[2].

[In Vivo]

MIF-1 (Melanostatin, 1 mg/kg; i.p.; once, for 1 hour; male Wistar rats) modulates the analgesic effects of morphine and stress-induced analgesia (SIA)[1]. MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats[3]. Animal Model: Male Wistar rats[1] Dosage: 1 mg/kg Administration: Intraperitoneal injection; once, for 1 hour Result: Decreased the analgesic effect of morphine. Increased the pain threshold for at least 1 h. Animal Model: Sprague-Dawley rats[3] Dosage: 1 mg/kg Administration: Intraperitoneal injection; daily, for 8 weeks Result: Attenuated the ontogenic impairment of striatal D2 receptors that was produced by spiroperidol (HY-B1371) treatment.

[References]

[1]. Bocheva A, et, al. Antiopioid properties of the TYR-MIF-1 family. Methods Find Exp Clin Pharmacol. 2004 Nov;26(9):673-7.

[2]. Valentijn JA, et, al. Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents. J Physiol. 1994 Mar 1;475(2):185-95.

[3]. Saleh MI, et, al. MIF-1 attenuates spiroperidol alteration of striatal dopamine D2 receptor ontogeny. Peptides. 1989 Jan-Feb;10(1):35-9.

Chemical & Physical Properties

[ Density]:
1.147g/cm3

[ Boiling Point ]:
626.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₂₄N₄O₃

[ Molecular Weight ]:
284.35500

[ Flash Point ]:
332.5ºC

[ Exact Mass ]:
284.18500

[ PSA ]:
113.32000

[ LogP ]:
0.68170

[ Vapour Pressure ]:
1.34E-15mmHg at 25°C

[ Index of Refraction ]:
1.51

MSDS

Click to get detail MSDS

Precursor & DownStream

Precursor

DownStream

Related Compounds

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