ALX 5407 hydrochloride

Names

[ CAS No. ]:
200006-08-2

[ Name ]:
ALX 5407 hydrochloride

[Synonym ]:
N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine Hydrochloride
ALX 5407 hydrochloride
187-1,N-WASP inhibitor
N-[3-(4'-Fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine hydrochloride
(+/-)-NFPS hydrochloride

Biological Activity

[Description]:

ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GlyT

[In Vitro]

ALX-5407 hydrochloride (0-1 mM) GlyT1- 或 GlyT2- 依赖地抑制甘氨酸转运，阻断大鼠大脑和 QT6-1C 细胞中 [3H] 甘氨酸的摄取，IC50 值为 3 nM[1]。 ALX-5407 hydrochloride (50 nM) 在 QT6-1C 细胞中表现出缓慢的解离动力学[1]。

[In Vivo]

ALX-5407 hydrochloride (1 和 10 mg/kg；口服，一次) 增加大鼠前额叶皮层游离甘氨酸水平[1]。

[References]

[1]. Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₅ClFNO₃

[ Molecular Weight ]:
429.91200

[ Exact Mass ]:
429.15100

[ PSA ]:
49.77000

[ LogP ]:
5.82130

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P273-P501

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 3077 9 / PGIII