ZCZ011

Names

[ CAS No. ]:
1998197-39-9

[ Name ]:
ZCZ011

[Synonym ]:
ZCZ011
1H-Indole, 6-methyl-3-[2-nitro-1-(2-thienyl)ethyl]-2-phenyl-
ZCZ-011
6-Methyl-3-[2-nitro-1-(2-thienyl)ethyl]-2-phenyl-1H-indole

Biological Activity

[Description]:

ZCZ011 is a potent and brain penetrant cannabinoid 1 (CB1) receptor positive allosteric modulator. ZCZ011 potentiates binding of CP55,940 to the CB1 receptor, enhances anandamide (AEA)-stimulated GTPγS binding in mouse brain membranes. ZCZ011 increases β-arrestin recruitment and ERK phosphorylation in hCB1 cells. ZCZ011 can be used for researching neuropathic and inflammatory pain[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

CB1[1]

[References]

[1]. Ignatowska-Jankowska BM, et al. A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects. Neuropsychopharmacology. 2015;40(13):2948-2959.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
602.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₈N₂O₂S

[ Molecular Weight ]:
362.44

[ Flash Point ]:
318.4±31.5 °C

[ Exact Mass ]:
362.108887

[ LogP ]:
6.37

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.677

Safety Information

[ Hazard Codes ]:
Xi