Lugdunin

Names

[ CAS No. ]:
1989698-37-4

[ Name ]:
Lugdunin

[Synonym ]:
(1R,4R,7S,10R,13S,16R,19S)-7-((1H-indol-3-yl)methyl)-10-isobutyl-4,13,16,19-tetraisopropyl-21-thia-3,6,9,12,15,18,23-heptaazabicyclo[18.2.1]tricosane-2,5,8,11,14,17-hexaone

Biological Activity

[Description]:

Lugdunin is an antibiotic peptide. Lugdunin inhibits bacteria by dissipating their membrane potential. Lugdunin is active against Gram-positive bacteria, such as S. aureus, and reduces S. aureus skin and nasal colonization. Lugdunin induces LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Bitschar K, et al. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat Commun. 2019 Jun 21;10(1):2730.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₆₂N₈O₆S

[ Molecular Weight ]:
783.03500

[ Exact Mass ]:
782.45100

[ PSA ]:
227.72000

[ LogP ]:
4.63560

Related Compounds

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