1989698-37-4

1989698-37-4 structure

Name: Lugdunin
Chemical Name: Lugdunin
CAS Number: 1989698-37-4
Molecular Formula: C₄₀H₆₂N₈O₆S
Molecular Weight: 783.03500
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-02-23 08:00:00
Modify Date: 2024-01-05 17:04:25
Lugdunin is an antibiotic peptide. Lugdunin inhibits bacteria by dissipating their membrane potential. Lugdunin is active against Gram-positive bacteria, such as S. aureus, and reduces S. aureus skin and nasal colonization. Lugdunin induces LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin[1].

Name	Lugdunin
Synonyms	(1R,4R,7S,10R,13S,16R,19S)-7-((1H-indol-3-yl)methyl)-10-isobutyl-4,13,16,19-tetraisopropyl-21-thia-3,6,9,12,15,18,23-heptaazabicyclo[18.2.1]tricosane-2,5,8,11,14,17-hexaone

Description	Lugdunin is an antibiotic peptide. Lugdunin inhibits bacteria by dissipating their membrane potential. Lugdunin is active against Gram-positive bacteria, such as S. aureus, and reduces S. aureus skin and nasal colonization. Lugdunin induces LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Bitschar K, et al. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat Commun. 2019 Jun 21;10(1):2730.