5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7-dihydro-10,11-dimethoxy-7-Methyl-

Names

[ CAS No. ]:
19843-03-9

[ Name ]:
5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7-dihydro-10,11-dimethoxy-7-Methyl-

[Synonym ]:
Dehydrodicentrine
Dehydrothalicmin
Dehydrodicentrin

Biological Activity

[Description]:

Dehydrodicentrine is an aporphine alkaloid can be isolated from the root of S. epigaea and has inhibitory effect on acetylcholinesterase (AChE) with an IC50 value of 2.98 μM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Dong JW, et al. Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea. Fitoterapia. 2015 Jul;104:102-7.

Chemical & Physical Properties

[ Boiling Point ]:
547.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₉NO₄

[ Molecular Weight ]:
337.37

[ Flash Point ]:
167.2ºC

[ Exact Mass ]:
337.13100

[ PSA ]:
40.16000

[ LogP ]:
3.79620

[ Vapour Pressure ]:
4.8E-12mmHg at 25°C

[ Index of Refraction ]:
1.681

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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