EphB3-IN-1

EphB3-IN-1 is the first potent, selective inhibitor of EphB3 that exhibits inhibiting EphB3 autophosphorylation in cells with IC50 of 3 nM; causes foremost inhibition of EphB3 in a panel of 98 kinases, except for RIPK2 and PHKG2; abolishes the EphB3 autophosphorylation at Y608 and Y614 at 100 nM.

References 1. Kung A, et al. J Am Chem Soc. 2016 Aug 24;138(33):10554-60. View Related Products by Target Ephrin Receptor