REV7/REV3L-IN-1

Names

[ CAS No. ]:
1979192-13-6

[ Name ]:
REV7/REV3L-IN-1

Biological Activity

[Description]:

REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 78 μM (REV7/REV3L interaction)[1]

[References]

[1]. Actis ML, et al. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction. Bioorg Med Chem. 2016 Sep 15;24(18):4339-4346.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₁N₃O₃S

[ Molecular Weight ]:
371.45

Related Compounds

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