1-Deoxysphinganine (m18:0)

Names

[ CAS No. ]:
196497-48-0

[ Name ]:
1-Deoxysphinganine (m18:0)

[Synonym ]:
Spisulosine
2S-amino-octadecan-3R-ol
1-deoxy-sphinganine
1-deoxysphinganine (0)
(2S,3R)-2-amino-3-hydroxyoctadecane
Spisulosine(2S,3R)-2-amino-3-hydroxy-octadecane ES-2851-deoxy SA1-deoxySa

Biological Activity

[Description]:

Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Cancer

Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

PKCζ

[References]

[1]. Ana M Sánchez, et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol. 2008 Apr 28;584(2-3):237-45.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₉NO

[ Molecular Weight ]:
285.50800

[ Exact Mass ]:
285.30300

[ PSA ]:
46.25000

[ LogP ]:
5.87610

Related Compounds

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