196497-48-0

196497-48-0 structure

Name: 1-Deoxysphinganine (m18:0)
Chemical Name: (2S,3R)-2-aminooctadecan-3-ol
CAS Number: 196497-48-0
Molecular Formula: C₁₈H₃₉NO
Molecular Weight: 285.50800
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2017-06-28 23:49:47
Modify Date: 2024-01-14 04:34:06
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation[1].

Name	(2S,3R)-2-aminooctadecan-3-ol
Synonyms	Spisulosine 2S-amino-octadecan-3R-ol 1-deoxy-sphinganine 1-deoxysphinganine (0) (2S,3R)-2-amino-3-hydroxyoctadecane Spisulosine(2S,3R)-2-amino-3-hydroxy-octadecane ES-2851-deoxy SA1-deoxySa

Description	Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCζ
References	[1]. Ana M Sánchez, et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol. 2008 Apr 28;584(2-3):237-45.