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gelatinase a

Names

[ CAS No. ]:
193807-58-8

[ Name ]:
gelatinase a

[Synonym ]:
D-Phenylalanine, N-([1,1'-biphenyl]-4-ylsulfonyl)-
N-(Biphenyl-4-ylsulfonyl)-D-phenylalanine
N-(4-Biphenylylsulfonyl)-D-phenylalanine

Biological Activity

[Description]:

MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC50s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[References]

[1]. Y Tamura, et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J Med Chem. 1998 Feb 12;41(4):640-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
595.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H19NO4S

[ Molecular Weight ]:
381.445

[ Flash Point ]:
314.2±32.9 °C

[ Exact Mass ]:
381.103485

[ LogP ]:
4.47

[ Appearance of Characters ]:
powder | light brown

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.627

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
B,Xi

[ Risk Phrases ]:
36/37/38-42

[ Safety Phrases ]:
23-26-36-24/25

[ WGK Germany ]:
2

Related Compounds