CBP-IN-1

Names

[ CAS No. ]:
1936431-44-5

[ Name ]:
CBP-IN-1

Biological Activity

[Description]:

CBP-IN-1 (compound 12) is a potent CBP inhibitor, with an IC50 of 1.5 nM. CBP-IN-1 also inhibits CBP BRET and BRD4(1), with IC50 values of 690 and 3100 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[References]

[1]. Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J Med Chem. 2017 Nov 22;60(22):9162-9183.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₃F₂N₇O

[ Molecular Weight ]:
509.59

Related Compounds

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