hACC2-IN-1

hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research[1].

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase

hACC2:2.5 μM (IC50)

ACC2 isoform, presents on the mitochondrial surface, inhibits carnitine palmitoyl transferase 1 (CPT-1) and converts acetyl-CoA into malonylCoA for de novo lipogenesis in the cytosol[1]. ACCs inhibition will change cellular substrate and favour lipid oxidation, thus preventing deleterious lipids from accumulating in oxidative tissue such as muscle, heart and liver[1]. hACC2-IN-1 shows good potency against the human ACC2 (hACC2) enzyme[1].

[1]. Bengtsson C, et al. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem. 2011 May 15;19(10):3039-53.