NTNCB hydrochloride

Names

[ CAS No. ]:
191931-56-3

[ Name ]:
NTNCB hydrochloride

[Synonym ]:
Benzenesulfonamide, 2-nitro-N-[[trans-4-[[[(1,2,3,4-tetrahydro-2-naphthalenyl)methyl]amino]methyl]cyclohexyl]methyl]-, hydrochloride (1:1)
2-Nitro-N-[[trans-4-[[[(1,2,3,4-tetrahydro-2-naphthalenyl)methyl]amino]methyl]cyclohexyl]methyl]benzenesulfonamide hydrochloride
2-Nitro-N-[(trans-4-{[(1,2,3,4-tetrahydro-2-naphthalenylmethyl)amino]methyl}cyclohexyl)methyl]benzenesulfonamide hydrochloride (1:1)

Biological Activity

[Description]:

NTNCB (Compound 11) hydrochloride is a potent and selective neuropeptide Y Y5 (NPY Y5) receptor antagonist with a Ki of 8 nM against human Y5[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[Target]

hY5 receptor:8 nM (Ki)

hY1 receptor:16032 nM (Ki)

[References]

[1]. Islam I, et al. Discovery of potent and selective small molecule NPY Y5 receptor antagonists. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1767-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₄ClN₃O₄S

[ Molecular Weight ]:
508.073

[ Exact Mass ]:
507.195862

[ Storage condition ]:
-20°C

Related Compounds

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