PF-04745637

Names

[ CAS No. ]:
1917294-46-2

[ Name ]:
PF-04745637

[Synonym ]:
PF-04745637

Biological Activity

[Description]:

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Inflammation/Immunology

[Target]

TRPA1:17 nM (IC50)

[In Vivo]

Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].

[References]

[1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₂ClF₃N₂O₂

[ Molecular Weight ]:
509.0033896

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.