1917294-46-2

1917294-46-2 structure

Name: PF-04745637
Chemical Name: 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
CAS Number: 1917294-46-2
Molecular Formula: C₂₇H₃₂ClF₃N₂O₂
Molecular Weight: 509.0033896
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2018-06-30 20:28:12
Modify Date: 2024-01-10 11:28:42
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].

Name	1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
Synonyms	PF-04745637

Description	PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Inflammation/Immunology
Target	TRPA1:17 nM (IC50)
In Vivo	Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].
References	[1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.

Molecular Formula	C₂₇H₃₂ClF₃N₂O₂
Molecular Weight	509.0033896