MONIRO-1

Names

[ CAS No. ]:
1909225-94-0

[ Name ]:
MONIRO-1

Biological Activity

[Description]:

MONIRO-1 is a T-type and N-type calcium channel blocker with IC50 values of 34, 3.3, 1.7 and 7.2 µM against hCav2.2, hCav3.1, hCav3.2 and hCav3.3, respectively[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Neurological Disease

[Target]

Cav3.1:3.3 μM (IC50)

Cav3.2:1.7 μM (IC50)

Cav3.3:7.2 μM (IC50)

Cav2.2:34 μM (IC50)

[References]

[1]. McArthur JR, et al. Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. Br J Pharmacol. 2018 Jun;175(12):2284-2295.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₄ClFN₄O₃

[ Molecular Weight ]:
458.91

Related Compounds

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