(R)-Lanicemine

Names

[ CAS No. ]:
190581-71-6

[ Name ]:
(R)-Lanicemine

Biological Activity

[Description]:

(R)-Lanicemine ((R)-AZD6765) is the less active R-enantiomer of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₄N₂

[ Molecular Weight ]:
198.26

(R)-Lanicemine

Names

Biological Activity

Chemical & Physical Properties

Related Compounds