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AZD9567

Names

[ CAS No. ]:
1893415-00-3

[ Name ]:
AZD9567

Biological Activity

[Description]:

AZD9567 (compound 15) is a potent, selective and oral active non-steroidal glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[Target]

IC50: 3.8 nM (Glucocorticoid receptor)[1].


[References]

[1]. Ripa L, et al. Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J Med Chem. 2018 Mar 8;61(5):1785-1799.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H28F2N4O3

[ Molecular Weight ]:
494.53

[ Storage condition ]:
2-8℃

Related Compounds