Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt

Names

[ Name ]:
Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt

[Synonym ]:
Ac-QKLVFF-NH2,amyloid blocker
Ac-QKLVFF-NH2
amyloid blocker
Acetyl-Amyloid |A-Protein Fragment 15-20 Amide
Ac-QKLVFF

Biological Activity

[Description]:

Acetly-β Amyloid (15-20), Amide is a peptides fragment. Acetly-β Amyloid (15-20), Amide inhibits the β-sheet formation and stabilizes structure of Aβ (1–40) peptide. Acetly-β Amyloid (15-20), Amide can be used in study Alzheimer’s disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Lin SY, et al. Fourier transform infrared spectroscopy used to evidence the prevention of beta-sheet formation of amyloid beta(1-40) peptide by a short amyloid fragment. Int J Biol Macromol. 2003 Sep;32(3-5):173-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₂H₆₂N₈O₉

[ Molecular Weight ]:
822.99000

[ Exact Mass ]:
822.46400

[ PSA ]:
281.01000

[ LogP ]:
4.32770

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Arrest of beta-amyloid fibril formation by a pentapeptide ligand.

J. Biol. Chem. 271 , 8545-8548, (1996)

Polymerization of amyloid beta-peptide (Abeta) into amyloid fibrils is a critical step in the pathogenesis of Alzheimer's disease. Here, we show that peptides incorporating a short Abeta fragment (KLV...

Controlling amyloid beta-peptide fibril formation with protease-stable ligands.

J. Biol. Chem. 272 , 12601-12605, (1997)

We have previously shown that short peptides incorporating the sequence KLVFF can bind to the approximately 40amino acid residue Alzheimer amyloid beta-peptide (Abeta) and disrupt amyloid fibril forma...