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L 760735

Names

[ CAS No. ]:
188923-01-5

[ Name ]:
L 760735

Biological Activity

[Description]:

L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

hNK1:0.19 nM (IC50)


[References]

[1]. Harrison T, et al. An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. J Med Chem. 2001 Nov 22;44(24):4296-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H29ClF7N5O2

[ Molecular Weight ]:
611.98

[ Exact Mass ]:
611.19000

[ PSA ]:
66.51000

[ LogP ]:
6.46030

Related Compounds