L 760735

Names

[ Name ]:
L 760735

Biological Activity

[Description]:

L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

hNK1:0.19 nM (IC50)

[References]

[1]. Harrison T, et al. An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. J Med Chem. 2001 Nov 22;44(24):4296-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₉ClF₇N₅O₂

[ Molecular Weight ]:
611.98

[ Exact Mass ]:
611.19000

[ PSA ]:
66.51000

[ LogP ]:
6.46030

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.