Temporin A

Names

[ Name ]:
Temporin A

[Synonym ]:
FLPLIGRVLSGIL
temporin A

Biological Activity

[Description]:

Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans)[1][1][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Temporin A (TA) is a small, basic, highly hydrophobic, antimicrobial peptide amide (FLPLIGRVLSGIL-NH2) found in the skin of the European red frog, Rana temporaria. It has variable antibiotic activities against a broad spectrum of microorganisms, including clinically important Methicillin-sensitive and -resistant Staphylococcus aureus as well as Vancomycin-resistant Enterococcus faecium strains[2].

[References]

[1]. Mäntylä T, Sirola H, Kansanen E, et al. Effect of temporin A modifications on its cytotoxicity and antimicrobial activity. APMIS. 2005;113(7-8):497-505.

[2]. Wade D, et al. Antibacterial activities of temporin A analogs. FEBS Lett. 2000;479(1-2):6-9.

[3]. Kamysz W, et al. Temporin A and its retro-analogues: synthesis, conformational analysis and antimicrobial activities. J Pept Sci. 2006;12(8):533-537.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₈H₁₁₇N₁₇O₁₄

[ Molecular Weight ]:
1396.76000

[ Exact Mass ]:
1395.90000

[ PSA ]:
491.65000

[ LogP ]:
5.64580

Related Compounds

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