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Rimeporide

Names

[ CAS No. ]:
187870-78-6

[ Name ]:
Rimeporide

[Synonym ]:
Rimeporide
UNII-QH6B4V5743

Biological Activity

[Description]:

Rimeporide is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Metabolic Disease

[Target]

NHE1[1]


[In Vitro]

Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent[1].

[References]

[1]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.


[Related Small Molecules]

EIPA | Riluzole | Ginsenoside Rg3 | Cariporide | Eleclazine hydrochloride | GS967 | Tenapanor | Triamterene | Ranolazine dihydrochloride | PF 05089771 | flecainide acetate | A-803467 | CNV1014802 (hydrochloride) | Zonisamide | Cinchocaine

Chemical & Physical Properties

[ Molecular Formula ]:
C11H15N3O5S2

[ Molecular Weight ]:
333.38400

[ Exact Mass ]:
333.04500

[ PSA ]:
167.50000

[ LogP ]:
2.96170

[ Storage condition ]:
2-8℃

Related Compounds