187870-78-6
187870-78-6 structure
- Name: Rimeporide
- Chemical Name: N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide
- CAS Number: 187870-78-6
- Molecular Formula: C11H15N3O5S2
- Molecular Weight: 333.38400
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
- Create Date: 2017-02-17 07:58:55
- Modify Date: 2024-01-02 12:02:33
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Rimeporide is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
| Name | N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide |
|---|---|
| Synonyms |
Rimeporide
UNII-QH6B4V5743 |
| Description | Rimeporide is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1). |
|---|---|
| Related Catalog | |
| Target |
NHE1[1] |
| In Vitro | Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent[1]. |
| References |
| Molecular Formula | C11H15N3O5S2 |
|---|---|
| Molecular Weight | 333.38400 |
| Exact Mass | 333.04500 |
| PSA | 167.50000 |
| LogP | 2.96170 |
| Storage condition | 2-8℃ |