2-NBDG

Names

[ Name ]:
2-NBDG

[Synonym ]:
2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose
D-Glucose, 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-
2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose
D-Glucopyranose, 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-
2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucopyranose

Biological Activity

[Description]:

2-NBDG is a fluorescent indicator for direct glucose uptake measurement and also is an indicator of cell viability.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[References]

[1]. Zou C, et al. 2-NBDG as a fluorescent indicator for direct glucose uptake measurement. J Biochem Biophys Methods. 2005 Sep 30;64(3):207-15.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.750±0.06 g/cm3

[ Boiling Point ]:
707.6±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₄N₄O₈

[ Molecular Weight ]:
342.262

[ Flash Point ]:
381.7±35.7 °C

[ Exact Mass ]:
342.081177

[ PSA ]:
186.92000

[ LogP ]:
-0.41

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.770

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
Very slightly soluble (0.48 g/L) (25 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.

Biomaterials 51 , 1-11, (2015)

Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer c...

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PLoS ONE 10 , e0132429, (2015)

Enhanced oxidative stress contributes to pathological changes in diabetes and its complications. Thus, strategies to reduce oxidative stress may alleviate these pathogenic processes. Herein, we have i...

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Eur. J. Med. Chem. 88 , 28-33, (2014)

Reversible oxidation of protein tyrosine phosphatases (PTPs) has emerged as an important regulatory mechanism whereby reactive oxygen species (ROS) inactivates the PTP and promotes phosphorylation and...