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6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

Names

[ CAS No. ]:
18592-13-7

[ Name ]:
6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

[Synonym ]:
6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione, 6-(chloromethyl)-
6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione
EINECS 242-431-9
6-chloromethylpyrimidine-2,4-dione
6-uracilylmethylchloride
MFCD00466419
6-Chloromethyluracil
6-(Chloromethyl)uracil

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
493.9ºC at 760 mmHg

[ Melting Point ]:
257 °C (dec.)(lit.)

[ Molecular Formula ]:
C5H5ClN2O2

[ Molecular Weight ]:
160.558

[ Flash Point ]:
252.5ºC

[ Exact Mass ]:
160.003952

[ PSA ]:
65.72000

[ LogP ]:
0.04

[ Vapour Pressure ]:
2.23E-10mmHg at 25°C

[ Index of Refraction ]:
1.511

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Precursor & DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

Bioorg. Med. Chem. 10(3) , 525-30, (2002)

A series of water soluble N(1)- and C(6)-substituted uracil pyridinium compounds were prepared as potential inhibitors of thymidine phosphorylase (TP). The C(6)-uracil substituted derivatives were the...

Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: discovery of novel orally active inhibitors of human thymidine phosphorylase.

Bioorg. Med. Chem. 12(13) , 3431-41, (2004)

A series of novel 6-methylene-bridged uracil derivatives have been prepared as inhibitors of human thymidine phosphorylase (TP). To enhance the in vivo antitumor activity of fluorinated pyrimidine 2'-...

Syntheses of novel heterocycles as anticancer agents.

Bioorg. Med. Chem. 13(10) , 3513-8, (2005)

Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCI-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as n...


More Articles


Related Compounds

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