ONO 2506

Names

[ Name ]:
ONO 2506

[Synonym ]:
2R-propyloctanoic acid
Artocarpesin

Biological Activity

[Description]:

Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid (ONO-2506) has been developed as a therapeutic agent for stroke and Alzheimer’s disease[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Tomoyuki Hasegawa, et al. Process Development of ONO-2506: A Therapeutic Agent for Stroke and Alzheimer's Disease. Org. Process Res. Dev.200372168-171.

[2]. Kato H, et al. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTPneurotoxicity in mice. Brain Res. 2004 Dec 24;1030(1):66-73.

Chemical & Physical Properties

[ Density]:
0.908 g/cm3

[ Boiling Point ]:
289.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₂₂O₂

[ Molecular Weight ]:
186.29100

[ Exact Mass ]:
186.16200

[ PSA ]:
37.30000

[ LogP ]:
3.45770

[ Vapour Pressure ]:
0.000557mmHg at 25°C

[ Index of Refraction ]:
1.444

Synthetic Route

Click to get detail synthetic route

Related Compounds

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