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IRAK4-IN-4

Names

[ CAS No. ]:
1850276-58-2

[ Name ]:
IRAK4-IN-4

Biological Activity

[Description]:

IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> IRAK
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IC50: 2.8 nM (IRAK4), 2.1 nM (cGAS)[1]


[References]

[1]. One class has the naphthalene second dione compounds and its derivative of protease modification activities. CN107163044A.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H16N2O2

[ Molecular Weight ]:
340.37

[ Storage condition ]:
2-8°C

Related Compounds