1850276-58-2

1850276-58-2 structure

Name: IRAK4-IN-4
Chemical Name: IRAK4-IN-4
CAS Number: 1850276-58-2
Molecular Formula: C₂₂H₁₆N₂O₂
Molecular Weight: 340.37
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2020-01-23 11:40:51
Modify Date: 2025-09-19 11:09:06
IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM[1].

Name	IRAK4-IN-4

Description	IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> IRAK Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IC50: 2.8 nM (IRAK4), 2.1 nM (cGAS)[1]
References	[1]. One class has the naphthalene second dione compounds and its derivative of protease modification activities. CN107163044A.