IRAK4-IN-16

Names

[ CAS No. ]:
1812188-83-2

[ Name ]:
IRAK4-IN-16

Biological Activity

[Description]:

IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC50 of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC50 values of 0.2, 0.2, 0.6, and 2.7 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> IRAK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IRAK4:2.5 ± 0.8 nM (IC50)


[References]

[1]. Chen Y, et al. Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma. Eur J Med Chem. 2020 Mar 15;190:112092.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H20F2N8O

[ Molecular Weight ]:
390.39

Related Compounds