PI3Kβ and δ inhibitor 20a

Names

[ Name ]:
PI3Kβ and δ inhibitor 20a

Biological Activity

[Description]:

PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kβ:7.8 nM (IC50)

PI3Kδ:5.3 nM (IC50)

PI3Kα:850 nM (IC50)

[References]

[1]. Perreault S, et al. Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. J Med Chem. 2017 Feb 23;60(4):1555-1567.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₄Cl₂FN₉O

[ Molecular Weight ]:
450.26

Related Compounds

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