1842380-77-1

1842380-77-1 structure

Name: PI3Kβ and δ inhibitor 20a
Chemical Name: PI3K-IN-6
CAS Number: 1842380-77-1
Molecular Formula: C₁₇H₁₄Cl₂FN₉O
Molecular Weight: 450.26
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2019-08-03 17:58:59
Modify Date: 2025-09-01 14:44:05
PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors[1].

Name	PI3K-IN-6

Description	PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kβ:7.8 nM (IC50) PI3Kδ:5.3 nM (IC50) PI3Kα:850 nM (IC50)
References	[1]. Perreault S, et al. Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. J Med Chem. 2017 Feb 23;60(4):1555-1567.

Molecular Formula	C₁₇H₁₄Cl₂FN₉O
Molecular Weight	450.26